diff --git a/src/main.cpp b/src/main.cpp
index 2c4da4c1f..cb7cb18f9 100644
--- a/src/main.cpp
+++ b/src/main.cpp
@@ -53,6 +53,13 @@ int main(int argc, char** argv)
 {
     QT_REQUIRE_VERSION(argc, argv, QT_VERSION_STR)
 
+#ifdef Q_OS_WIN
+    // Set OPENSSL_CONF and OPENSSL_MODULES to an invalid location to prevent DLL injection via openssl.cnf.
+    // vcpkg by default hard-codes this to its packages location, which may be user-writable.
+    qputenv("OPENSSL_CONF", "::");
+    qputenv("OPENSSL_MODULES", "::");
+#endif
+
     QApplication::setAttribute(Qt::AA_EnableHighDpiScaling);
     QGuiApplication::setAttribute(Qt::AA_UseHighDpiPixmaps);
 #if QT_VERSION >= QT_VERSION_CHECK(5, 14, 0) && defined(Q_OS_WIN)